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Each of the three pathways contributes different effects: GI Side Effects (Primarily from GLP-1) The GLP-1 component is responsible for most gastrointestinal side effects because it slows gastric emptying and affects gut motility: Metabolic Effects (From Glucagon Component) The glucagon component may cause slight increases in: Heart rate: Average increase of 5-10 bpm due to increased metabolic rate (similar to tirzepatide) Body temperature: Some users report feeling warmer, especially after meals (thermogenesis) Energy levels: Variable
ACS Omega 4(2):42334242
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